Description

3-(4-Chloro-1-Guanidinoisoquinolin-7-Yl)Benzoic Acid Hydrate is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate of significant pharmaceutical importance. This compound is valued for its role as a key building block in the synthesis of novel antiviral and antiretroviral active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development and production of next-generation therapeutics targeting HIV and other viral infections, where consistent quality and reliable supply are critical.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of advanced non-nucleoside reverse transcriptase inhibitor (NNRTI) drug candidates.
• Antiviral API Development: Used in research and development for creating new antiretroviral agents targeting HIV-1 and other retroviruses.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies to optimize potency and reduce resistance in antiviral compounds.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for scale-up and cGMP production of clinical trial materials and commercial APIs.
• Biochemical Research: Employed in biochemical assays to study enzyme inhibition mechanisms and viral replication pathways.

Basic Information

Product Name	3-(4-Chloro-1-Guanidinoisoquinolin-7-Yl)Benzoic Acid Hydrate
CAS No.	423158-56-9
Molecular Formula	C₁₇H₁₄ClN₅O₃
Molecular Weight	371.78 g/mol
Synonyms	3-(4-Chloro-1-guanidino-7-isoquinolinyl)benzoic acid hydrate; 3-(4-Chloro-1-guanidinoisoquinolin-7-yl)benzoic acid monohydrate; 7-[3-(Carboxyphenyl)]-4-chloro-1-guanidinoisoquinoline hydrate; NNRTI Intermediate 423158-56-9; 1-Guanidino-4-chloro-7-(3-carboxyphenyl)isoquinoline hydrate; Benzoic acid, 3-(4-chloro-1-guanidino-7-isoquinolinyl)-, hydrate (1:1)
EINECS	Contact for details

Quality Control

Every batch of 3-(4-Chloro-1-Guanidinoisoquinolin-7-Yl)Benzoic Acid Hydrate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for pharmaceutical R&D and cGMP manufacturing. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.