Description

1-Isoquinolineacetic Acid, 1,2,3,4-Tetrahydro-6,7-Dimethoxy-, Methyl Ester, (1S)- is a high-purity, chiral synthetic intermediate of significant importance in advanced organic synthesis. This compound matters because its complex, functionalized tetrahydroisoquinoline core serves as a critical building block for the development of active pharmaceutical ingredients (APIs) and other fine chemicals. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors seeking to develop novel compounds with specific stereochemistry.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potential therapeutic agents, particularly those targeting the central nervous system.
• Alkaloid Synthesis: Used in the construction of complex natural product analogs and tetrahydroisoquinoline-based alkaloids for biological screening.
• Asymmetric Catalysis Research: Serves as a sophisticated substrate or ligand precursor in the development of new catalytic methodologies.
• Agrochemical Development: Employed in research for creating novel crop protection agents with specific modes of action.
• Chemical Biology Probes: Utilized to build molecular tools for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical component for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	1-Isoquinolineacetic Acid, 1,2,3,4-Tetrahydro-6,7-Dimethoxy-, Methyl Ester, (1S)-
CAS No.	417725-91-8
Molecular Formula	C₁₄H₁₉NO₄
Molecular Weight	265.31 g/mol
Synonyms	(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-isoquinolineacetic acid methyl ester; Methyl (1S)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline-1-acetate; (S)-Methyl 1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline-1-acetate; (S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-isoquinolineacetic acid methyl ester; (S)-Tetrahydro-6,7-dimethoxy-1-isoquinolineacetic acid methyl ester; (S)-THIQ-DM-ME; (S)-Methyl tetrahydro-6,7-dimethoxyisoquinoline-1-acetate
EINECS	Contact for details

Quality Control

Our 1-Isoquinolineacetic Acid, 1,2,3,4-Tetrahydro-6,7-Dimethoxy-, Methyl Ester, (1S)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment to guarantee traceability and consistency for your critical synthetic workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); ensure containers are sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.