Description

1-(2-Chloromethoxy-Ethyl)-5-Fluoro-1H-Indole-2,3-Dione is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated isatin core structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncological pathways.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of complex APIs that incorporate the 5-fluoro-isatin moiety.
• Biochemical Probe Development: Employed in the creation of chemical probes for studying enzyme inhibition and protein-ligand interactions.
• Fine Chemical Production: An important intermediate for custom synthesis and contract manufacturing organizations (CMOs) serving the life sciences sector.

Basic Information

Product Name	1-(2-Chloromethoxy-Ethyl)-5-Fluoro-1H-Indole-2,3-Dione
CAS No.	416899-86-0
Molecular Formula	C11H9ClFNO3
Molecular Weight	257.65 g/mol
Synonyms	5-Fluoro-1-(2-chloromethoxyethyl)indoline-2,3-dione; 1-(2-Chloromethoxyethyl)-5-fluoroindoline-2,3-dione; 5-Fluoro-1-(2-chloroethoxymethyl)isatin; 416899-86-0; 5-Fluoro-1-(2-chloromethoxyethyl)isatin; 1-(2-Chloroethoxymethyl)-5-fluoroisatin; 5-Fluoro-1-(2-chloroethoxymethyl)indoline-2,3-dione
EINECS	Contact for details

Quality Control

Our 1-(2-Chloromethoxy-Ethyl)-5-Fluoro-1H-Indole-2,3-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.