Description

Dl-Homocysteine-3,3,4,4-D4 is a stable isotope-labeled analog of the sulfur-containing amino acid homocysteine, where four hydrogen atoms are replaced by deuterium. This compound is an essential internal standard and tracer in quantitative analytical methods, providing unmatched accuracy for metabolic and clinical research. It is primarily required by pharmaceutical R&D laboratories, diagnostic kit manufacturers, and academic institutions conducting advanced studies in cardiovascular disease, homocysteinemia, and metabolic pathway analysis.

Application

• Internal Standard for LC-MS/MS Analysis: Critical for the precise quantification of homocysteine in complex biological matrices like plasma, serum, and urine in clinical diagnostics and research.
• Metabolic Tracer Studies: Used in in vitro and in vivo research to elucidate the methionine cycle, transsulfuration pathway, and homocysteine metabolism using mass spectrometry.
• Diagnostic Assay Development: A key component in the calibration and validation of commercial immunoassays and chromatographic kits for homocysteine testing.
• Pharmaceutical Research: Employed in drug discovery and development to study the pharmacokinetics and efficacy of compounds targeting homocysteine-related disorders.
• Stable Isotope Dilution Assays (SIDA): Serves as the ideal reference compound to ensure method accuracy and compensate for sample preparation losses and instrument variability.
• Nutritional and Biochemical Research: Facilitates studies on the impact of vitamins (B6, B12, folate) on homocysteine levels and related health outcomes.

Basic Information

Product Name	Dl-Homocysteine-3,3,4,4-D4
CAS No.	416845-90-4
Molecular Formula	C4H5D4NO2S
Molecular Weight	139.20 g/mol (for D4 isotopologue)
Synonyms	DL-Homocysteine-d4; (±)-Homocysteine-3,3,4,4-d4; 2-Amino-4-sulfanylbutanoic-3,3,4,4-d4 acid; Homocysteine-d4; Deuterated Homocysteine; Hcy-d4; 2-Amino-4-mercaptobutyric acid-d4; (RS)-Homocysteine-d4
EINECS	Contact for details

Quality Control

Our Dl-Homocysteine-3,3,4,4-D4 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (atom % D), chemical purity (by HPLC), and identity confirmation. We adhere to relevant industry standards for research chemicals, ensuring reliable and reproducible performance in your laboratory.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (atom % D)	≥ 98.0% (by MS)
Chemical Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.