Description

Grapiprant CAS NO 415903-37-6 is a selective prostaglandin E2 (PGE2) EP4 receptor antagonist, representing a significant advancement in targeted therapeutic agents. This compound is valued for its precise mechanism of action, offering a high degree of specificity for modulating inflammatory and pain pathways. It is primarily utilized by pharmaceutical research organizations and manufacturers engaged in the development of novel anti-inflammatory and analgesic medications for veterinary and potential human health applications.

Application

• Veterinary Pharmaceuticals: Key active pharmaceutical ingredient (API) in non-steroidal anti-inflammatory drugs (NSAIDs) for canine osteoarthritis pain management.
• Preclinical Research: Used as a reference standard and tool compound in pharmacological studies targeting the EP4 receptor pathway.
• Drug Discovery & Development: Serves as a lead compound or intermediate in the synthesis of new EP4 receptor antagonists for various inflammatory conditions.
• Analytical Testing: Employed as a high-purity certified reference material (CRM) for method development and quality control in analytical laboratories.
• Academic Research: Facilitates studies in immunology and inflammation to elucidate the role of PGE2 and its receptors in disease models.

Basic Information

Product Name	Grapiprant
CAS No.	415903-37-6
Molecular Formula	C20H18F3N3O4
Molecular Weight	421.37 g/mol
Synonyms	Grapiprant; CJ-023,423; (R)-2-[3-[(2-Fluoro-4-methoxyphenyl)methyl]-4,5-dihydro-5-oxo-1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-1-yl]-3-pyridinepropanoic acid; 1H-1,2,4-Triazole-1-propanoic acid, 3-[(2-fluoro-4-methoxyphenyl)methyl]-4,5-dihydro-5-oxo-1-(2,2,2-trifluoroethyl)-, (αR)-; Galliprant (Veterinary Trade Name)
EINECS	Contact for details

Quality Control

Our Grapiprant is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets high-grade pharmaceutical standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurities is provided with every shipment to guarantee traceability and batch-to-batch consistency for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (R-enantiomer)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.