Description

(R)-3-(2-Chloroacetyl)Thiazolidine-4-Carbonitrile is a high-value chiral building block and synthetic intermediate of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, which incorporates a thiazolidine ring, a nitrile group, and a reactive chloroacetyl moiety, enabling its use in constructing complex, biologically active molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for applications in medicinal chemistry and asymmetric synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel drug candidates, especially those targeting neurological and metabolic disorders.
• Asymmetric Synthesis: Utilized as a versatile building block for constructing complex, stereochemically defined molecules due to its (R)-configured stereocenter.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization processes in drug discovery pipelines.
• Peptidomimetic Development: The thiazolidine scaffold is valuable for creating peptidomimetics and constrained peptide analogs.
• Chemical Biology Probes: Used in the synthesis of specialized probes for studying enzyme mechanisms and biological pathways.
• Agrochemical Research: Acts as an intermediate in the development of new, high-performance crop protection agents with specific chiral activity.

Basic Information

Product Name	(R)-3-(2-Chloroacetyl)Thiazolidine-4-Carbonitrile
CAS No.	412293-40-4
Molecular Formula	C6H7ClN2OS
Molecular Weight	190.65 g/mol
Synonyms	(R)-3-(Chloroacetyl)-4-cyanothiazolidine; (4R)-3-(2-Chloroacetyl)-1,3-thiazolidine-4-carbonitrile; (R)-3-(2-Chloroacetyl)thiazolidine-4-carbonitrile; 412293-40-4; (R)-3-Chloroacetyl-4-cyanothiazolidine; 4-Cyano-3-(chloroacetyl)-(R)-thiazolidine
EINECS	Contact for details

Quality Control

Our (R)-3-(2-Chloroacetyl)Thiazolidine-4-Carbonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data, including chiral purity (enantiomeric excess) verification by HPLC. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with each batch to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.