Description

7-(Trifluoromethyl)Isoquinolin-1(2H)-One is a high-value trifluoromethyl-substituted isoquinolinone derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both the isoquinolinone scaffold and a metabolically stable trifluoromethyl group, makes it indispensable for creating novel compounds with enhanced biological activity and physicochemical properties. This intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the discovery of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in oncology, CNS disorders, and anti-inflammatory therapies.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group to improve efficacy and environmental stability.
• Material Science Precursor: Employed in the development of advanced organic electronic materials, such as OLEDs and semiconductors, due to its electron-deficient aromatic system.
• Fluorine Chemistry Building Block: Essential for medicinal chemists exploring structure-activity relationships (SAR) by introducing fluorine atoms to modulate lipophilicity, metabolic stability, and bioavailability.
• Chemical Biology Probe Development: Serves as a core structure for designing molecular probes and inhibitors to study enzyme function and biological pathways.

Basic Information

Product Name	7-(Trifluoromethyl)Isoquinolin-1(2H)-One
CAS No.	410086-28-1
Molecular Formula	C10H6F3NO
Molecular Weight	213.16 g/mol
Synonyms	1(2H)-Isoquinolinone, 7-(trifluoromethyl)-; 7-(Trifluoromethyl)-1,2-dihydroisoquinolin-1-one; 7-(Trifluoromethyl)-1H-isoquinolin-1-one; 7-Trifluoromethylisoquinolin-1(2H)-one; 7-Trifluoromethyl-1,2-dihydroisoquinolin-1-one; 410086-28-1; 7-(Trifluoromethyl)-2H-isoquinolin-1-one
EINECS	Contact for details

Quality Control

Our 7-(Trifluoromethyl)Isoquinolin-1(2H)-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.