Description

α-Acetamino-α-Carboxy-(3-Indole)-Butyric Acid CAS NO 408537-42-8 is a specialized indole derivative building block of significant interest in advanced organic synthesis. This compound serves as a critical intermediate for the development of complex molecules, particularly in pharmaceutical research and development. It is primarily sought after by research chemists and process development scientists in the life sciences sector for constructing novel active pharmaceutical ingredients (APIs) and other biologically active compounds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting neurological and oncological pathways.
• Peptidomimetic Research: Used in the design and synthesis of peptide analogs and mimetics due to its indole and carboxylic acid functionalities.
• Chemical Biology Probes: Serves as a precursor for creating labeled compounds or probes used in biochemical and cellular assays.
• Agrochemical Synthesis: Potential intermediate in the development of new plant growth regulators or agrochemicals with specific biological activity.
• Academic & Contract Research: Employed in university and CRO (Contract Research Organization) settings for methodological development and exploratory chemistry.
• Custom Synthesis: Foundation for the custom manufacturing of proprietary compounds for clients in the biotechnology and pharmaceutical industries.

Basic Information

Product Name	α-Acetamino-α-Carboxy-(3-Indole)-Butyric Acid
CAS No.	408537-42-8
Molecular Formula	C₁₅H₁₆N₂O₅
Molecular Weight	304.30 g/mol
Synonyms	2-Acetamido-2-carboxy-4-(1H-indol-3-yl)butanoic acid; 2-Acetamido-4-(1H-indol-3-yl)-2,4-dicarboxybutanoic acid; 3-Indolebutyric acid, α-acetamido-α-carboxy-; α-Acetamido-α-carboxy-3-indolebutyric acid; ACBIB; N-Acetyl-α,α-dicarboxy-3-indolebutyric acid; (2R/S)-2-Acetamido-4-(1H-indol-3-yl)-2,4-dicarboxybutanoic acid (racemic mixture)
EINECS	Contact for details

Quality Control

Our α-Acetamino-α-Carboxy-(3-Indole)-Butyric Acid is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP (current Good Manufacturing Practice) principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Individual unknown impurity ≤ 0.5% Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.