Description

Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-amino- (9Ci) is a highly strained, cage-like bicyclic amino acid derivative that serves as a valuable and versatile building block in modern organic synthesis. Its unique three-dimensional structure, characterized by the [1.1.1]propellane core, is prized for imparting improved metabolic stability, enhanced lipophilicity, and novel spatial geometry to target molecules. This compound is primarily sought after by medicinal chemists and researchers in the pharmaceutical and agrochemical industries for applications in drug discovery, bioisostere development, and the synthesis of complex bioactive compounds.

Application

• Pharmaceutical Intermediate: A key synthon for incorporating the rigid bicyclo[1.1.1]pentane scaffold into drug candidates, potentially improving potency and ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) properties.
• Bioisostere Development: Used as a three-dimensional bioisostere for tert-butyl, phenyl, or alkyne groups to modulate the physicochemical and pharmacological profiles of lead compounds.
• Agrochemical Research: Employed in the synthesis of novel pesticides and herbicides where the unique steric and electronic properties can lead to new modes of action.
• Material Science Precursor: Serves as a starting material for synthesizing novel polymers, ligands, or metal-organic frameworks (MOFs) with tailored properties.
• Chemical Biology Probe: Utilized in the design and synthesis of chemical probes to study enzyme function or protein-protein interactions.
• Peptidomimetics: Incorporated into peptide chains to create constrained analogues with enhanced stability against enzymatic degradation.

Basic Information

Product Name	Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-amino- (9Ci)
CAS No.	406947-32-8
Molecular Formula	C7H11NO2
Molecular Weight	141.17 g/mol
Synonyms	3-Aminobicyclo[1.1.1]pentane-1-carboxylic acid; 3-Amino-BCP-COOH; 1-Carboxy-3-aminobicyclo[1.1.1]pentane; 3-Amino-1-bicyclo[1.1.1]pentanecarboxylic acid; BCP-NH2-COOH; (3-Aminobicyclo[1.1.1]pentan-1-yl)formic acid; 3-Aminopentacyclo[4.1.0.0²,⁴.0³,⁵.0⁶,⁸]octane-1-carboxylic acid (alternative systematic name); 3-Amino-BCP acid
EINECS	Contact for details

Quality Control

Our Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-amino- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent chemical identity, meeting the stringent requirements for research and development applications. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature: 2-8°C (refrigerated) for optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95.0% (Area %)
Assay (Titration)	≥97.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.