Description

4-Bromo-3-Iodoindole-1-Carboxylic Acid tert-Butyl Ester is a high-value, multi-halogenated indole derivative that serves as a critical synthetic intermediate in advanced organic chemistry. This compound is essential for constructing complex molecular architectures, particularly in the development of novel pharmaceuticals and bioactive compounds. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for targeted synthesis and lead optimization.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialized polymers and organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and enzyme functions.
• Cross-Coupling Reactions: The bromo and iodo substituents make it an excellent substrate for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Academic & Contract Research: A valuable reagent for methodological development and complex natural product synthesis in academic and CRO laboratories.

Basic Information

Product Name	4-Bromo-3-Iodoindole-1-Carboxylic Acid tert-Butyl Ester
CAS No.	406170-09-0
Molecular Formula	C₁₃H₁₃BrINO₂
Molecular Weight	422.06 g/mol
Synonyms	1H-Indole-1-carboxylic acid, 4-bromo-3-iodo-, 1,1-dimethylethyl ester; tert-Butyl 4-bromo-3-iodo-1H-indole-1-carboxylate; 4-Bromo-3-iodo-1H-indole-1-carboxylic acid tert-butyl ester; 4-Bromo-3-iodoindole-1-carboxylic acid t-butyl ester; Boc-protected 4-bromo-3-iodoindole; 4-Br-3-I-1H-indole-1-COOtBu
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-Iodoindole-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.