Description

4-Chloro-3-Iodoindole-1-Carboxylic Acid tert-Butyl Ester is a high-value, multi-functional indole derivative serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both chloro and iodo substituents on the indole core, makes it an indispensable intermediate for constructing complex heterocyclic compounds. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, agrochemical development, and materials science.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly for targeting neurological and oncological pathways.
• Agrochemical Research: Used to develop new active ingredients for crop protection agents, leveraging its halogenated indole scaffold.
• Chemical Biology Probes: Serves as a versatile scaffold for creating molecular probes to study enzyme function and protein interactions.
• Material Science: Building block for advanced organic electronic materials and functional polymers due to its electron-rich indole system.
• Cross-Coupling Reactions: The iodo and chloro groups are excellent substrates for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings.
• Peptidomimetics & Macrocycle Synthesis: Used to incorporate constrained, halogenated indole motifs into peptide backbones and cyclic structures.

Basic Information

Product Name	4-Chloro-3-Iodoindole-1-Carboxylic Acid tert-Butyl Ester
CAS No.	406170-08-9
Molecular Formula	C13H13ClINO2
Molecular Weight	377.61 g/mol
Synonyms	1H-Indole-1-carboxylic acid, 4-chloro-3-iodo-, 1,1-dimethylethyl ester; tert-Butyl 4-chloro-3-iodo-1H-indole-1-carboxylate; 4-Chloro-3-iodo-1H-indole-1-carboxylic acid tert-butyl ester; 4-Chloro-3-iodoindole-1-tert-butyl carboxylate; 1-Boc-4-chloro-3-iodoindole; 4-Cl-3-I-1H-indole-1-COOtBu; 406170-08-9; Boc-4-chloro-3-iodoindole
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Iodoindole-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We employ advanced analytical techniques including HPLC, GC-MS, and NMR to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.