Description

5-Bromo-3-(4-Fluorobenzoyl)-1H-Indole is a high-purity, advanced pharmaceutical intermediate characterized by its indole core functionalized with bromo and fluorobenzoyl groups. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel bioactive molecules. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in oncology and CNS drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potential drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of new chemical entities.
• Kinase Inhibitor Development: Serves as a core structure in the research and synthesis of small molecule kinase inhibitors for cancer therapy.
• Biochemical Probe Synthesis: Employed in creating specialized probes for studying enzyme function and cellular signaling mechanisms.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Utilized in university and institutional labs for exploratory organic synthesis and heterocyclic chemistry studies.

Basic Information

Product Name	5-Bromo-3-(4-Fluorobenzoyl)-1H-Indole
CAS No.	405275-13-0
Molecular Formula	C15H9BrFNO
Molecular Weight	318.14 g/mol
Synonyms	5-Bromo-3-(4-fluorobenzoyl)-1H-indole; 1H-Indole, 5-bromo-3-(4-fluorobenzoyl)-; 3-(4-Fluorobenzoyl)-5-bromo-1H-indole; 5-Bromo-3-(p-fluorobenzoyl)indole; 405275-13-0; 5-Bromo-3-(4-fluorobenzoyl)indole; AKOS005258889
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-(4-Fluorobenzoyl)-1H-Indole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.