Description

Bicyclo[2.1.1]Hexane-1-Methanol, -α-,5,5-Trimethyl-, (-α-R,1R,4R)-Rel- (9Ci) is a high-purity, stereochemically defined bicyclic building block of significant interest in advanced organic synthesis. Its unique, rigid three-dimensional structure makes it a valuable scaffold for medicinal chemistry, enabling the exploration of novel chemical space and the modulation of physicochemical properties in drug candidates. This compound is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of complex, bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a sophisticated chiral building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) disorders and metabolic diseases.
• Medicinal Chemistry Scaffold: Used to introduce conformational rigidity and three-dimensionality into lead compounds, potentially improving target selectivity, metabolic stability, and bioavailability.
• Agrochemical Research: Employed in the development of novel pesticides and herbicides, where its unique bicyclic framework can contribute to new modes of action.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the research of specialty polymers with tailored thermal and mechanical properties.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce high enantioselectivity.
• Chemical Biology Probe: Incorporated into molecular probes to study protein-ligand interactions and enzyme mechanisms due to its defined stereochemistry and potential for functionalization.

Basic Information

Product Name	Bicyclo[2.1.1]Hexane-1-Methanol, -α-,5,5-Trimethyl-, (-α-R,1R,4R)-Rel- (9Ci)
CAS No.	404825-38-3
Molecular Formula	C10H18O
Molecular Weight	154.25 g/mol
Synonyms	(1R,4R)-rel-5,5-Trimethylbicyclo[2.1.1]hexane-1-methanol; rel-(1R,4R)-5,5-Trimethylbicyclo[2.1.1]hexane-1-methanol; Bicyclo[2.1.1]hexane-1-methanol, 5,5-dimethyl-, (1R,4R)-rel-; Trimethylbicyclohexanemethanol; (αR,1R,4R)-rel-α,5,5-Trimethylbicyclo[2.1.1]hexane-1-methanol
EINECS	Contact for details

Quality Control

Our Bicyclo[2.1.1]Hexane-1-Methanol, -α-,5,5-Trimethyl-, (-α-R,1R,4R)-Rel- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure consistent identity, purity, and stereochemical integrity. Comprehensive Certificates of Analysis (COA) detailing assay, enantiomeric excess, and impurity profiles are provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.