Description

n-Desethyl Brinzolamide is a key pharmaceutical intermediate and metabolite of the carbonic anhydrase inhibitor brinzolamide. This compound is of significant importance for research and development in the ophthalmic pharmaceutical sector, particularly for the synthesis and analytical study of next-generation intraocular pressure-lowering agents. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in drug development, metabolite profiling, and quality control processes for ophthalmic solutions.

Application

• Pharmaceutical Intermediate: Critical starting material or building block in the synthesis of brinzolamide and its novel derivatives.
• Reference Standard: Used as a certified reference material (CRM) or analytical standard in HPLC, LC-MS, and GC-MS for quantitative and qualitative analysis.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the metabolism, distribution, and excretion of brinzolamide.
• Impurity Profiling: Employed to identify, quantify, and control desethyl-related impurities in brinzolamide active pharmaceutical ingredient (API) batches to meet ICH guidelines.
• Research & Development: Facilitates biological activity studies and the development of new carbonic anhydrase inhibitors for treating glaucoma.
• Quality Assurance/Control (QA/QC): Serves as a benchmark in analytical laboratories to ensure the purity, potency, and safety of brinzolamide-based drug products.

Basic Information

Item	Detail
Product Name	n-Desethyl Brinzolamide
CAS No.	404034-55-5
Molecular Formula	C11H14N2O4S2
Molecular Weight	302.37 g/mol
Synonyms	4-(Ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-Dioxide; Desethyl Brinzolamide; Brinzolamide Desethyl Metabolite; Brinzolamide Impurity C; Brinzolamide Related Compound C; AL-4862 Desethyl; (R)-Desethyl Brinzolamide
EINECS	Contact for details

Quality Control

Our n-Desethyl Brinzolamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by IR and NMR, purity assay by HPLC, and control of specific impurities, to ensure it meets the stringent requirements for pharmaceutical reference standards and intermediates. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with in-house specifications aligned with ICH Q3A/B guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.