Description

4H-Thieno[2,3-B]Thiopyran-4-Amine,n-Ethyl-5,6-Dihydro-6-Methyl-, 7,7-Dioxide, (4S,6S) is a high-purity, stereochemically defined chiral intermediate of significant interest in advanced organic synthesis. This compound matters for its role as a critical building block in the development of novel, complex molecules, particularly within the pharmaceutical sector. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the fine chemical and pharmaceutical industries who require reliable, high-quality intermediates for API synthesis and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic agents.
• Medicinal Chemistry Research: Used in the design, synthesis, and structure-activity relationship (SAR) studies of new chemical entities due to its unique fused heterocyclic structure.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale manufacturing of drug candidates, where consistent quality and stereochemical purity are paramount.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in catalytic asymmetric transformations to construct complex molecular architectures.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development, quality control, and regulatory submissions.
• Custom Synthesis Building Block: Provides a versatile core structure for contract research organizations (CROs) and custom synthesis houses developing proprietary compounds for clients.

Basic Information

Product Name	4H-Thieno[2,3-B]Thiopyran-4-Amine,n-Ethyl-5,6-Dihydro-6-Methyl-, 7,7-Dioxide, (4S,6S)
CAS No.	403848-01-1
Molecular Formula	C10H15NO2S2
Molecular Weight	245.36 g/mol
Synonyms	(4S,6S)-N-Ethyl-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-4-amine 7,7-dioxide; (4S,6S)-N-Ethyl-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-amine 7,7-dioxide; 4H-Thieno[2,3-b]thiopyran-4-amine, N-ethyl-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S,6S)-; Chiral Thienothiopyran Amine Dioxide; CAS 403848-01-1
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high stereochemical purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, 1H/13C NMR for structural confirmation, and tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.