Description

1H-Inden-1-Ol, 3-Amino-2,3-Dihydro-, (1R,3R)-Rel- (9Ci) is a high-purity chiral amino alcohol derivative of indene, serving as a critical advanced pharmaceutical intermediate (API) and a versatile chiral building block in asymmetric synthesis. Its defined stereochemistry at the 1 and 3 positions makes it invaluable for constructing complex molecular architectures with high enantiomeric purity. This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, cardiovascular diseases, and anti-inflammatory agents.
• Asymmetric Catalysis: Employed as a precursor for chiral ligands or catalysts in enantioselective transformations, such as hydrogenations and C-C bond formations.
• Agrochemical Research: Building block for developing novel, stereospecific pesticides and herbicides with enhanced efficacy and environmental profiles.
• Fine Chemical Synthesis: Used in the multi-step synthesis of complex natural products, flavors, and fragrances requiring specific stereocenters.
• Academic & R&D: Serves as a standard or starting material in methodological chemistry research focused on new synthetic routes and stereochemistry control.

Basic Information

Product Name	1H-Inden-1-Ol, 3-Amino-2,3-Dihydro-, (1R,3R)-Rel- (9Ci)
CAS No.	403671-97-6
Molecular Formula	C9H11NO
Molecular Weight	149.19 g/mol
Synonyms	(1R,3R)-rel-3-Amino-2,3-dihydro-1H-inden-1-ol; rel-(1R,3R)-3-Aminoindan-1-ol; 3-Amino-1-indanol (rel-(1R,3R)-form); (1R,3R)-3-Aminoindan-1-ol (racemic relative configuration); Aminoindanol derivative; Chiral 3-Aminoindanol; CAS 403671-97-6
EINECS	Contact for details

Quality Control

Our production of 1H-Inden-1-Ol, 3-Amino-2,3-Dihydro-, (1R,3R)-Rel- (9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination and identity confirmation by spectroscopic methods. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment. We support cGMP-compliant manufacturing for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% (rel-(1R,3R))
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.