Description

Mercaptopolyethylene Glycol Monomethyl Etherpeg-Thiol is a functionalized polyethylene glycol derivative featuring a terminal thiol (-SH) group. This compound is a critical building block in bioconjugation and polymer chemistry, enabling the formation of stable thioether linkages with maleimides, vinyl sulfones, and other reactive partners. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and materials science sectors who require reliable, high-purity PEGylation reagents for drug delivery systems, surface modification, and hydrogel synthesis.

Application

• Bioconjugation Reagent: For site-specific coupling of peptides, proteins, and antibodies to create stable PEGylated therapeutics and diagnostics.
• Polymer Synthesis: As a chain transfer agent (CTA) or functional monomer in the synthesis of thiol-terminated polymers and block copolymers via controlled radical polymerization.
• Surface Functionalization: For creating self-assembled monolayers (SAMs) on gold, silver, or other metal surfaces to impart biocompatibility and anti-fouling properties.
• Hydrogel Cross-linking: Utilized in the formation of disulfide-crosslinked or Michael addition-based hydrogels for tissue engineering and controlled drug release applications.
• Nanoparticle Modification: For the surface PEGylation of quantum dots, liposomes, and polymeric nanoparticles to improve stability, solubility, and circulation time in vivo.
• Diagnostic Assay Development: Used to label biomolecules with fluorescent or other reporter groups for use in immunoassays and biosensors.

Basic Information

Product Name	Mercaptopolyethylene Glycol Monomethyl Etherpeg-Thiol
CAS No.	401916-61-8
Molecular Formula	Typically CnH2n+2OmS (Variable based on PEG chain length)
Molecular Weight	Variable (Contact for details on specific molecular weight grades)
Synonyms	mPEG-Thiol; α-Methoxy-ω-mercapto poly(ethylene glycol); Methoxy PEG Thiol; HS-PEG-OMe; Poly(ethylene glycol) methyl ether thiol; PEG-SH (monomethyl ether terminated); Thiol-PEG-OMe; ω-Thiol-α-methoxy poly(oxy-1,2-ethanediyl)
EINECS	Contact for details

Quality Control

Our Mercaptopolyethylene Glycol Monomethyl Etherpeg-Thiol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent molecular weight distribution, and functional group integrity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications for assay, thiol content, polydispersity, and residual solvents. We support compliance with cGMP and ISO 9001 standards for critical pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation of the thiol group and maintain product stability. For long-term storage, desiccate to prevent moisture absorption. Allow the product to equilibrate to room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or waxy solid
Identification (IR)	Conforms to structure
Assay (Thiol Content)	≥ 95%
PEG Chain Length (n, average)	As per customer requirement (e.g., 5, 10, 20 kDa)
Polydispersity Index (PDI)	≤ 1.05 (by GPC)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.