Description

Carotegrast is a small molecule integrin antagonist with significant therapeutic potential. This compound is primarily of interest for its targeted anti-inflammatory action, offering a mechanism for modulating immune responses. It is a key material for research and development in the pharmaceutical industry, particularly for investigating treatments for inflammatory bowel diseases and other chronic inflammatory conditions. Carotegrast CAS NO 401904-75-4 represents a high-purity, research-grade chemical for advanced biomedical applications.

Application

• Pharmaceutical R&D: Primary use as an active pharmaceutical ingredient (API) intermediate or reference standard in drug discovery programs.
• Inflammatory Disease Research: Critical for preclinical studies targeting conditions like ulcerative colitis and Crohn's disease due to its integrin inhibition properties.
• Biochemical Assay Development: Used as a precise tool compound to study α4β7 integrin pathways and cell adhesion mechanisms in vitro.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in API manufacturing.
• Mechanistic Studies: Employed in academic and industrial research to elucidate the pharmacodynamics of gut-selective anti-inflammatory agents.

Basic Information

Product Name	Carotegrast
CAS No.	401904-75-4
Molecular Formula	C₂₀H₂₅N₃O₅
Molecular Weight	387.43 g/mol
Synonyms	AJM300; (2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-Acetamido-3-phenylpropanoyl]amino]-3-phenylpropanoyl]pyrrolidin-2-yl]formamido]acetic Acid; UNII-9J486B4F3V; Carotegrast Methyl; AJM 300; 9J486B4F3V; α4β7 Integrin Antagonist AJM300
EINECS	Contact for details

Quality Control

Our Carotegrast is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry guidelines for research chemicals, and specifications can be aligned with client requirements for advanced R&D use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.