Description

Tenapanor Hydrochloride is a high-purity, non-systemic sodium-hydrogen exchanger 3 (NHE3) inhibitor used in pharmaceutical research and development. This compound is critical for advancing therapeutic programs targeting hyperphosphatemia and irritable bowel syndrome with constipation (IBS-C). It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in API synthesis, preclinical studies, and formulation development.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Serves as the key chemical entity for the manufacture of finished drug products.
• Preclinical & Clinical Research: Used in pharmacological and toxicological studies to evaluate efficacy and safety profiles.
• Reference Standard: Acts as a primary standard in analytical method development and validation (HPLC, LC-MS).
• Formulation Development: Employed in the R&D of solid oral dosage forms, such as tablets and capsules.
• Process Chemistry: Used for scaling up synthetic routes and optimizing manufacturing processes.
• Regulatory Submissions: Provides the necessary quality material for compiling Chemistry, Manufacturing, and Controls (CMC) documentation.

Basic Information

Product Name	Tenapanor Hydrochloride
CAS No.	1234365-97-9
Molecular Formula	C44H46ClN7O6S2 • xHCl
Molecular Weight	Contact for details
Synonyms	Tenapanor HCl; AZD-1722 Hydrochloride; RDX-5798; 6-[(5S)-5-(2,3-Dihydro-1-benzofuran-5-yl)-1-methyl-1,2,3,4-tetrahydroquinolin-6-yl]-N-[(2S)-1-hydroxypropan-2-yl]-5-methyl-2-propyl-3-pyridinecarboxamide hydrochloride; 1,2,3,4-Tetrahydro-6-[5-[(5S)-5-(2,3-dihydro-5-benzofuranyl)-1-methyl-1,2,3,4-tetrahydro-6-quinolinyl]-1-methyl-2-propyl-1H-imidazole-4-carboxamido]-2,3-pyridinedicarboxylic acid hydrochloride; NHE3 Inhibitor Tenapanor HCl
EINECS	Contact for details

Quality Control

Our Tenapanor Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, suitable for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results from tests including HPLC assay, related substances, residual solvents, and identification.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.