Description

D-Erythro-Pentitol, 1,4-Anhydro-3-o-[Bis(4-Methoxyphenyl)Phenylmethyl]-2-Deoxy-, 2-Cyanoethyl Bis(1-Methylethyl)Phosphoramidite (9Ci) is a sophisticated phosphoramidite monomer, a critical building block in the automated solid-phase synthesis of oligonucleotides. This compound matters because it enables the precise and efficient incorporation of modified nucleosides, which are essential for developing advanced therapeutic nucleic acids like antisense oligonucleotides and siRNAs. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and CROs specializing in oligonucleotide-based drug discovery and development.

Application

• Oligonucleotide Synthesis: As a key phosphoramidite monomer for the solid-phase synthesis of modified DNA/RNA strands.
• Antisense Drug Development: For the production of antisense oligonucleotides (ASOs) used in targeted gene silencing therapies.
• siRNA and miRNA Synthesis: Enables the creation of small interfering RNA (siRNA) and microRNA (miRNA) constructs for RNA interference applications.
• Research Probes and Primers: Used to synthesize labeled or modified oligonucleotides for diagnostic assays, PCR primers, and hybridization probes.
• Aptamer Development: In the synthesis of chemically modified aptamers for therapeutic and diagnostic purposes.
• Scale-Up Manufacturing: Suitable for transitioning from milligram-scale research to gram and kilogram-scale production under cGMP conditions.

Basic Information

Product Name	D-Erythro-Pentitol, 1,4-Anhydro-3-o-[Bis(4-Methoxyphenyl)Phenylmethyl]-2-Deoxy-, 2-Cyanoethyl Bis(1-Methylethyl)Phosphoramidite (9Ci)
CAS No.	401813-16-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1,4-Anhydro-3-O-[bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-D-erythro-pentitol, 2-cyanoethyl bis(1-methylethyl)phosphoramidite; DMT-Protected Phosphoramidite; Nucleoside Phosphoramidite Monomer; DMT-2'-Deoxyribonucleoside Phosphoramidite (Analog); 5'-O-(4,4'-Dimethoxytrityl)-2'-Deoxynucleoside 3'-(2-Cyanoethyl N,N-Diisopropylphosphoramidite) (Related Class); MMTr Phosphoramidite; Oligonucleotide Synthesis Reagent.
EINECS	Contact for details

Quality Control

Every batch of our high-purity phosphoramidite monomers undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and performance in synthesis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality management system supports development under research and cGMP-grade standards for advanced therapeutic applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will compromise purity and reactivity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in anhydrous acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.