Description

tert-Butyl n-Succinimidyl N,N'-Hexamethylenedicarbamate is a specialized bifunctional cross-linking reagent featuring a succinimidyl ester and a tert-butyl carbamate-protected amine. This compound matters as a critical building block in bioconjugation and peptide synthesis, enabling the controlled formation of stable amide bonds. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for developing antibody-drug conjugates (ADCs), protein labeling, and advanced polymer chemistry.

Application

• Antibody-Drug Conjugate (ADC) Linker Synthesis: Serves as a key intermediate for constructing cleavable or non-cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• Peptide & Protein Modification: Used for site-specific labeling or functionalization of peptides, proteins, and enzymes via amine-reactive succinimidyl ester chemistry.
• Polymer & Biomaterial Functionalization: Enables the introduction of protected amine groups into polymer backbones for subsequent controlled cross-linking or further derivatization.
• Solid-Phase Peptide Synthesis (SPPS): Acts as a protected linker or handle for the synthesis of complex peptide sequences requiring orthogonal protection strategies.
• Diagnostic Reagent Development: Utilized in the creation of fluorescent or other reporter-labeled probes for immunoassays and imaging applications.
• Surface Immobilization Chemistry: Facilitates the covalent attachment of biomolecules to chips, beads, or other solid supports for biosensor and microarray platforms.

Basic Information

Product Name	tert-Butyl n-Succinimidyl N,N'-Hexamethylenedicarbamate
CAS No.	401792-94-7
Molecular Formula	C17H27N3O6
Molecular Weight	369.42 g/mol
Synonyms	1,6-Bis[(tert-butoxycarbonyl)amino]hexane N-hydroxysuccinimide ester; N,N'-Bis(Boc)-1,6-diaminohexane NHS ester; Nα,Nω-Bis(tert-butoxycarbonyl)-1,6-hexanediamine N-succinimidyl ester; Nα,Nω-Di-Boc-1,6-hexanediamine NHS ester; Boc-Hex(NHS)-Boc; (Boc)2-Hex-NHS; N,N'-Di-Boc-1,6-hexanediamine N-hydroxysuccinimide diester; tert-Butyl N-(6-{[(tert-butoxy)carbonyl]amino}hexyl)carbamate 2,5-dioxopyrrolidin-1-yl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl n-Succinimidyl N,N'-Hexamethylenedicarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research and cGMP-grade material standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.