Description

4-Bromo-1-(Piperazin-1-yl)isoquinoline is a high-value, heterocyclic organic compound featuring a fused isoquinoline core substituted with a bromine atom and a piperazine moiety. This specific molecular architecture makes it a critical pharmacological intermediate and a versatile building block in advanced organic synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly within medicinal chemistry programs targeting kinase inhibition and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, especially kinase inhibitors and other small-molecule therapeutics.
• Medicinal Chemistry Research: Used as a core scaffold or a functionalized fragment for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Chemical Biology Probes: Employed in the development of molecular probes to study enzyme function and biological pathways.
• Organic Synthesis Building Block: The reactive bromine and the secondary amine on the piperazine ring allow for further functionalization via cross-coupling reactions and amide bond formation.
• Academic & Industrial R&D: Essential for research in heterocyclic chemistry and the development of new synthetic methodologies.

Basic Information

Product Name	4-Bromo-1-(Piperazin-1-yl)isoquinoline
CAS No.	401567-96-2
Molecular Formula	C₁₃H₁₄BrN₃
Molecular Weight	292.18 g/mol
Synonyms	4-Bromo-1-piperazinylisoquinoline; 1-(4-Bromoisoquinolin-1-yl)piperazine; 4-Bromo-1-(1-piperazinyl)isoquinoline; 1-Piperazinyl-4-bromoisoquinoline; 401567-96-2; 4-Bromo-1-piperazinyl-isoquinoline; 4-Bromo-1-(piperazin-1-yl)isoquinoline; 4-Bromo-1-(piperazin-1-yl)isoquinoline
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-(Piperazin-1-yl)isoquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to standard
Assay (HPLC)	≥97.0%
Purity (HPLC Area %)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.