Description

tert-Butyl 4-(5-Bromo-2,3-Dihydro-1H-Indol-1-Yl)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique indole-piperidine scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in central nervous system (CNS) and oncology drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Protease Inhibitor Development: The structural motif is valuable for creating inhibitors targeting specific proteases involved in disease pathways.
• Kinase Inhibitor Synthesis: Serves as a building block for the development of novel kinase inhibitors for cancer and inflammatory diseases.
• CNS Drug Discovery: Employed in the research of potential therapeutics for neurological and psychiatric disorders.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic Research: Used in university and institutional labs for chemical biology and novel synthetic methodology development.

Basic Information

Product Name	tert-Butyl 4-(5-Bromo-2,3-Dihydro-1H-Indol-1-Yl)Piperidine-1-Carboxylate
CAS No.	401565-86-4
Molecular Formula	C18H25BrN2O2
Molecular Weight	381.31 g/mol
Synonyms	1-Boc-4-(5-Bromo-2,3-dihydro-1H-indol-1-yl)piperidine; 1-(1-Boc-4-Piperidinyl)-5-Bromoindoline; 5-Bromo-1-(1-(tert-butoxycarbonyl)piperidin-4-yl)indoline; tert-Butyl 4-(5-bromo-2,3-dihydro-1H-indol-1-yl)piperidine-1-carboxylate; 401565-86-4; 4-(5-Bromo-2,3-dihydro-1H-indol-1-yl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 1,1-Dimethylethyl 4-(5-bromo-2,3-dihydro-1H-indol-1-yl)-1-piperidinecarboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(5-Bromo-2,3-Dihydro-1H-Indol-1-Yl)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under inert atmosphere when appropriate for prolonged procedures to ensure stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.