Description

6-Cyanoamino-Indazole-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected intermediate in organic synthesis, specifically designed for the construction of complex heterocyclic scaffolds. Its core value lies in providing a versatile and reactive handle for the controlled introduction of the cyanoamino-indazole moiety into target molecules under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly those developing novel kinase inhibitors, anticancer agents, and other biologically active compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel indazole-based drug candidates, including kinase inhibitors and anticancer agents.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with novel modes of action.
• Chemical Biology: Serves as a precursor for designing molecular probes and enzyme inhibitors to study biological pathways.
• Organic Synthesis: A versatile reagent for constructing complex heterocyclic systems and introducing functional groups in medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of advanced intermediates under cGMP or research-grade conditions.

Basic Information

Product Name	6-Cyanoamino-Indazole-1-Carboxylic Acid tert-Butyl Ester
CAS No.	401510-60-9
Molecular Formula	C₁₃H₁₄N₄O₂
Molecular Weight	258.28 g/mol
Synonyms	tert-Butyl 6-cyanoamino-1H-indazole-1-carboxylate; 1H-Indazole-1-carboxylic acid, 6-(aminocarbonyl)-, 1,1-dimethylethyl ester; 6-Cyanoamino-1H-indazole-1-carboxylic acid tert-butyl ester; 6-Carbamoyl-1H-indazole-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-6-cyanoaminoindazole; BOC-6-Cyanoaminoindazole
EINECS	Contact for details

Quality Control

Our 6-Cyanoamino-Indazole-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC, NMR, and MS, to verify identity and purity. A Certificate of Analysis (COA) is supplied with each batch, detailing all relevant specifications. Our quality system supports development from research to commercial scale, with capabilities for producing material under current Good Manufacturing Practice (cGMP) guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.