Description

n-Boc-5-Aminoisoindoline is a high-purity, protected amine derivative that serves as a critical building block in advanced organic synthesis. This compound is essential for the efficient and selective construction of complex molecular architectures, particularly in pharmaceutical research and development. It is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of isoindoline-based drug candidates, including potential kinase inhibitors and central nervous system (CNS) active compounds.
• Peptidomimetic Synthesis: Used in the design and synthesis of peptidomimetics and constrained peptides, where the isoindoline scaffold provides structural rigidity.
• Agrochemical Research: Serves as a versatile building block for developing new active ingredients in crop protection and pest management.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized as a precursor for fluorescent tags, affinity probes, and other tools for biological target identification and validation.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes under GMP or non-GMP conditions.

Basic Information

Product Name	n-Boc-5-Aminoisoindoline
CAS No.	400727-63-1
Molecular Formula	C₁₃H₁₈N₂O₂
Molecular Weight	234.29 g/mol
Synonyms	5-Aminoisoindoline-1-carboxylic acid tert-butyl ester; tert-Butyl 5-aminoisoindoline-1-carboxylate; 1-Boc-5-aminoisoindoline; 5-Amino-1-N-Boc-isoindoline; 1-(tert-Butoxycarbonyl)-5-aminoisoindoline; 5-Amino-2,3-dihydro-1H-isoindole-1-carboxylic acid tert-butyl ester; Boc-5-AI
EINECS	Contact for details

Quality Control

Our n-Boc-5-Aminoisoindoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material suitable for research use, non-GMP, or GMP applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.