Description

5-(3-Bromophenyl)Isothiazole is a high-purity brominated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of a bromine substituent and an isothiazole ring, enabling precise functionalization and the construction of complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the isothiazole moiety can contribute to biological activity.
• Material Science: Acts as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology: Employed as a probe or linker in bioconjugation chemistry and for the development of enzyme inhibitors.
• Cross-Coupling Reactions: The aryl bromide functionality makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Sonogashira couplings to create diverse biaryl structures.
• Library Synthesis: A valuable scaffold for generating diverse compound libraries in high-throughput screening for drug discovery programs.

Basic Information

Product Name	5-(3-Bromophenyl)Isothiazole
CAS No.	49602-96-2
Molecular Formula	C9H6BrNS
Molecular Weight	240.12 g/mol
Synonyms	3-Bromo-5-phenylisothiazole; 5-(3-Bromophenyl)-1,2-thiazole; 3-Bromophenylisothiazole; Isothiazole, 5-(3-bromophenyl)-; 5-(m-Bromophenyl)isothiazole; 1,2-Thiazole, 5-(3-bromophenyl)-
EINECS	Contact for details

Quality Control

Our 5-(3-Bromophenyl)Isothiazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.