Description

2-Methyl-1,4-Naphthoquinone-D8 is a deuterated analog of menadione, a synthetic form of vitamin K, where eight hydrogen atoms are replaced with deuterium. This isotopic labeling is critical for providing an internal standard in mass spectrometry, ensuring unparalleled accuracy and reliability in quantitative analytical methods. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, nutritional science, and advanced chemical synthesis sectors who require precise measurement and metabolic tracing of vitamin K compounds.

Application

• Internal Standard for LC-MS/MS: Primary use as a stable isotope-labeled internal standard for the precise quantification of menadione and related vitamin K compounds in complex biological matrices, food, and pharmaceutical products.
• Pharmaceutical Research & Development: Enables accurate pharmacokinetic and metabolic studies of vitamin K analogs, supporting drug discovery and development efforts.
• Nutritional Science & Food Analysis: Used in the analysis of vitamin K content and stability in fortified foods, dietary supplements, and animal feed.
• Deuterated Building Block: Serves as a specialized starting material or intermediate in the synthesis of more complex deuterated compounds for research purposes.
• Quality Control & Reference Material: Acts as a high-purity reference standard to validate analytical methods and ensure the accuracy of assay results in GMP/GLP environments.

Basic Information

Product Name	2-Methyl-1,4-Naphthoquinone-D8
CAS No.	47817-80-1
Molecular Formula	C11D8O2
Molecular Weight	180.25 g/mol
Synonyms	Menadione-D8; Vitamin K3-D8; 2-Methyl-1,4-naphthalenedione-D8; 2-Methyl-1,4-dihydro-1,4-diketonaphthalene-D8; 2-Methyl-1,4-naphthoquinone (octadeutero); 2-Methyl-3-(2-methyl-1,4-naphthoquinonyl)-D8; 2-Methylnaphthoquinone-D8
EINECS	Contact for details

Quality Control

Our 2-Methyl-1,4-Naphthoquinone-D8 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay (by HPLC), deuterium enrichment (by NMR or MS), and impurity profile. We adhere to relevant industry standards for reference materials, ensuring reliable and reproducible performance in your sensitive analytical methods.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. Keep the container in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Deuterium Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.