Description

Ethyl 1,2,3,4-Tetrahydroisoquinoline-4-Carboxylate is a versatile heterocyclic building block and chiral intermediate of significant importance in advanced organic synthesis. Its core tetrahydroisoquinoline scaffold is a privileged structure in medicinal chemistry, making it a critical precursor for the development of active pharmaceutical ingredients (APIs) and fine chemicals. This compound is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex molecules with potential biological activity.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of tetrahydroisoquinoline-based APIs, including potential candidates for central nervous system (CNS) disorders, cardiovascular drugs, and antimicrobial agents.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that incorporate the tetrahydroisoquinoline moiety for enhanced efficacy.
• Fine Chemical Production: Serves as a precursor for dyes, pigments, and other specialty chemicals requiring complex heterocyclic structures.
• Asymmetric Catalysis & Ligand Synthesis: Employed in the development of chiral ligands and catalysts for stereoselective synthesis, crucial for producing enantiomerically pure compounds.
• Academic & Contract Research: Essential reagent for methodological development in organic chemistry and for exploring new chemical spaces in drug discovery programs.

Basic Information

Product Name	Ethyl 1,2,3,4-Tetrahydroisoquinoline-4-Carboxylate
CAS No.	46389-19-9
Molecular Formula	C₁₂H₁₅NO₂
Molecular Weight	205.25 g/mol
Synonyms	Ethyl 1,2,3,4-tetrahydro-4-isoquinolinecarboxylate; 4-Carbethoxy-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydroisoquinoline-4-carboxylic acid ethyl ester; Ethyl tetrahydroisoquinoline-4-carboxylate; 4-Ethoxycarbonyl-1,2,3,4-tetrahydroisoquinoline; (RS)-Ethyl 1,2,3,4-tetrahydroisoquinoline-4-carboxylate; (±)-Ethyl 1,2,3,4-tetrahydro-4-isoquinolinecarboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 1,2,3,4-Tetrahydroisoquinoline-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the stringent requirements of our global clientele. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.