Description

4-Hydroxypyridine-D5 is a deuterated derivative of 4-hydroxypyridine, a key heterocyclic compound where five hydrogen atoms are replaced with deuterium. This isotopic labeling is crucial for creating internal standards in analytical chemistry, enhancing the precision and reliability of quantitative mass spectrometry. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors for metabolic studies, drug development, and reaction mechanism elucidation.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference standard for the accurate quantification of 4-hydroxypyridine and related metabolites in complex biological matrices.
• Pharmaceutical Research & Development: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies, drug metabolism and disposition (DMPK) investigations, and bioanalytical method development.
• Metabolic Pathway Tracing: Enables detailed tracking and analysis of biochemical pathways and degradation products in environmental and life sciences.
• Chemical Synthesis & Catalysis Research: Acts as a deuterated building block or probe in the synthesis of labeled compounds and for studying reaction mechanisms via isotopic effects.
• Agrochemical Analysis: Employed in the residue analysis and environmental fate studies of pyridine-based pesticides and herbicides.
• Forensic & Clinical Toxicology: Supports the precise identification and quantification of specific analytes in forensic and clinical diagnostic assays.

Basic Information

Product Name	4-Hydroxypyridine-D5
CAS No.	45503-33-1
Molecular Formula	C5D5NO
Molecular Weight	101.13 g/mol
Synonyms	4-Pyridinol-D5; 4-Pyridone-D5; γ-Hydroxypyridine-D5; 4-Hydroxypyridine (phenyl-D5); 4(1H)-Pyridinone-D5; 4-Oxopyridine-D5; 1H-Pyridin-4-one-D5; Deuterated 4-Hydroxypyridine
EINECS	Contact for details

Quality Control

Every batch of 4-Hydroxypyridine-D5 is produced and tested under stringent quality management protocols to ensure exceptional isotopic purity and chemical integrity. Our products undergo rigorous quality testing, including NMR and mass spectrometry, to confirm deuterium incorporation and chemical purity, ensuring compliance with research and analytical standards. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content, NMR)	≥98 atom % D
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.