Description

Methyl-D3 Chloroformate CAS NO 43049-56-5 is a stable isotope-labeled derivative of methyl chloroformate, where three hydrogen atoms are replaced by deuterium. This compound is a critical reagent for introducing a labeled methyl ester group in organic synthesis, enabling precise tracking and quantification in analytical studies. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry sectors for applications in drug metabolism studies, pharmacokinetics, and the synthesis of isotopically labeled standards for mass spectrometry.

Application

• Pharmaceutical Research & Development: Key intermediate for synthesizing deuterium-labeled active pharmaceutical ingredients (APIs) and metabolites for drug discovery and development.
• Mass Spectrometry & Analytical Standards: Used to prepare internal standards for Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS), improving analytical accuracy and reproducibility.
• Metabolite Identification & Pharmacokinetics (PK): Essential in tracing metabolic pathways and conducting absorption, distribution, metabolism, and excretion (ADME) studies.
• Agrochemical Research: Employed in the synthesis of isotopically labeled pesticides and herbicides to study environmental fate and degradation.
• Organic Synthesis: Acts as a versatile methylating and carbonylating agent in the preparation of complex, labeled organic molecules.
• Biochemical Tracing: Useful in proteomics and other biochemical assays where stable isotope labeling is required for quantitative analysis.

Basic Information

Product Name	Methyl-D3 Chloroformate
CAS No.	43049-56-5
Molecular Formula	C2D3ClO2
Molecular Weight	98.50 g/mol
Synonyms	Deuterated Methyl Chloroformate; Methyl-d3 Chloroformate; (Trideuteriomethyl) carbonochloridate; Chloroformic Acid-d3 Methyl Ester; Methyl Chloroformate-d3; CD3OCOCl; Methyl-d3 Chlorocarbonate
EINECS	Contact for details

Quality Control

Our Methyl-D3 Chloroformate is produced under strict quality control protocols to ensure high isotopic and chemical purity. Each batch is characterized using advanced analytical techniques, including NMR (Nuclear Magnetic Resonance) and mass spectrometry, to confirm deuterium incorporation and chemical identity. Certificates of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles are provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 99.0 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.