Description

Trimethyl-D9-Acetic Acid is a high-purity, deuterium-labeled isotopologue of trimethylacetic acid (pivalic acid), where nine hydrogen atoms are replaced by deuterium. This compound is an essential stable isotope-labeled building block, providing critical utility in analytical chemistry for creating internal standards and metabolic tracers. It is primarily used by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for applications requiring precise quantification and mechanistic studies.

Application

• Pharmaceutical Research & Development: Serves as a key precursor or internal standard in the synthesis and quantitative analysis of deuterated active pharmaceutical ingredients (APIs) and metabolites using LC-MS and GC-MS.
• Metabolic Pathway Tracing: Used in mass spectrometry-based studies to trace biochemical pathways and understand drug metabolism and pharmacokinetics (DMPK).
• Agrochemical Analysis: Employed as a stable isotope-labeled standard for the accurate detection and quantification of pesticides, herbicides, and their degradation products in environmental and food safety testing.
• NMR Spectroscopy Solvent & Reagent: Acts as a useful deuterated reagent or shift reference in nuclear magnetic resonance (NMR) spectroscopy due to its isotopic purity.
• Organic Synthesis Intermediate: Functions as a specialized building block for synthesizing more complex deuterated compounds for research in material science and catalysis.
• Forensic & Clinical Toxicology: Utilized in the development of highly accurate analytical methods for detecting and quantifying substances in complex biological matrices.

Basic Information

Product Name	Trimethyl-D9-Acetic Acid
CAS No.	42983-07-3
Molecular Formula	C5D9HO2 / (CD3)3CCOOD
Molecular Weight	107.17 g/mol (deuterated form)
Synonyms	Perdeuterated Pivalic Acid; (Trideuteriomethyl)-D6-acetic Acid; 2,2-Dimethylpropanoic-3,3,3-D9 Acid; Pivalic Acid-D9; (CD3)3CCOOD; Trimethylacetic Acid-d9; t-Butyl-D9-carboxylic Acid; 2,2-Dimethylpropionic Acid-D9
EINECS	Contact for details

Quality Control

Our Trimethyl-D9-Acetic Acid is manufactured under controlled conditions to ensure exceptional isotopic and chemical purity, suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (Atom % D), chemical purity by NMR or HPLC, and specific impurity profiles. We adhere to stringent quality management protocols to guarantee batch-to-batch consistency and reliability for your research and production needs.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive). Store in a cool, dry place at room temperature (15-25°C) under an inert atmosphere if the container is repeatedly opened. Keep the original container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR / NMR)	Conforms to structure
Isotopic Enrichment (Atom % D)	≥ 98% (by MS or NMR)
Chemical Purity (HPLC / NMR)	≥ 98%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.