Description

Methyl-D3-Malonic Acid CAS NO 42522-59-8 is a stable isotope-labeled analog of malonic acid, where three hydrogen atoms are replaced by deuterium atoms. This high-purity compound is essential for applications requiring precise internal standards in quantitative mass spectrometry analysis. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry sectors for drug metabolism studies, environmental analysis, and advanced organic synthesis.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference compound for the accurate quantification of malonic acid and related metabolites in complex biological matrices like plasma, urine, and tissue samples.
• Pharmaceutical Research & Development: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies to track drug metabolism pathways and ensure analytical method validation under regulatory guidelines (e.g., FDA, EMA).
• Metabolomics and Biomarker Discovery: Enables precise measurement in metabolic flux analysis, helping to identify disease biomarkers and understand biochemical pathways.
• Synthesis of Deuterated Compounds: Acts as a key building block for the synthesis of more complex deuterium-labeled intermediates and active pharmaceutical ingredients (APIs).
• Environmental and Food Safety Testing: Facilitates the detection and quantification of trace analytes in environmental monitoring and food contaminant analysis.
• NMR Spectroscopy: Useful as a deuterated reagent or standard in nuclear magnetic resonance spectroscopy studies.

Basic Information

Product Name	Methyl-D3-Malonic Acid
CAS No.	42522-59-8
Molecular Formula	C3D3HO4
Molecular Weight	121.09 g/mol
Synonyms	Malonic Acid-d3 Methyl Ester; Methyl Malonate-d3; Methyl Malonic Acid-d3; Methyl Propanedioate-d3; Deuterated Methyl Malonate; (Carboxy-d)Acetic Acid Methyl Ester; 2-Methoxy-2-oxoacetic-2-d acid; Methyl Hydrogen Malonate-d3
EINECS	Contact for details

Quality Control

Our Methyl-D3-Malonic Acid is manufactured under strict quality control protocols to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (D atom %), chemical purity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality system is designed to meet the stringent requirements of research and regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D atom %)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.