Description

5-Chloro-α-(Hydroxyimino)Thiophen-2-Acetonitrile is a specialized heterocyclic building block featuring a reactive nitrile and oxime functional group on a chlorinated thiophene scaffold. This compound matters as a critical intermediate for synthesizing advanced pharmaceutical agents and high-performance agrochemicals, enabling the construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, particularly in therapeutic areas requiring thiophene-based heterocycles.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides.
• Material Science Research: Serves as a precursor for organic electronic materials, such as conductive polymers or organic semiconductors.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes under cGMP conditions.
• Academic & Industrial R&D: Employed in discovery chemistry for exploring new chemical spaces and reaction methodologies.

Basic Information

Product Name	5-Chloro-α-(Hydroxyimino)Thiophen-2-Acetonitrile
CAS No.	42520-76-3
Molecular Formula	C7H3ClN2OS
Molecular Weight	198.63 g/mol
Synonyms	5-Chloro-2-(hydroxyimino)(thien-2-yl)acetonitrile; 2-(5-Chloro-2-thienyl)-2-(hydroxyimino)acetonitrile; (5-Chloro-2-thienyl)(hydroxyimino)acetonitrile; 5-Chloro-α-(hydroxyimino)-2-thiopheneacetonitrile; 5-Chloro-2-thiopheneglyoxylonitrile oxime; (Z)-2-(5-Chlorothiophen-2-yl)-2-(hydroxyimino)acetonitrile; 42520-76-3; 5-Chloro-α-hydroxyiminothiophene-2-acetonitrile
EINECS	Contact for details

Quality Control

Our 5-Chloro-α-(Hydroxyimino)Thiophen-2-Acetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material suitable for research use and can supply grades aligned with cGMP standards for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.