Description

Glycine-2,2-D2-n-T-Boc is a deuterium-labeled derivative of the amino acid glycine, protected with a tert-butoxycarbonyl (Boc) group. This compound is a critical building block in advanced research, particularly for the synthesis of isotopically labeled peptides and proteins used in mass spectrometry and NMR studies. It is essential for scientists in pharmaceutical R&D, academic research, and contract research organizations (CROs) who require high-purity, stable-isotope labeled precursors for metabolic studies, proteomics, and structural biology.

Application

• Stable Isotope Labeling: Synthesis of deuterium-labeled peptides and proteins for use as internal standards in quantitative mass spectrometry (MS) and proteomics.
• NMR Spectroscopy: As a probe in nuclear magnetic resonance (NMR) studies to investigate protein structure, dynamics, and molecular interactions without signal interference from natural abundance isotopes.
• Metabolic Pathway Tracing: Incorporation into compounds to trace and elucidate biochemical pathways and drug metabolism in pharmacokinetic and pharmacodynamic (PK/PD) research.
• Pharmaceutical Intermediate: A key protected intermediate in the solid-phase and solution-phase synthesis of complex bioactive peptides and glycopeptides.
• Proteomics Research: Used in the development of selective reaction monitoring (SRM) and parallel reaction monitoring (PRM) assays for accurate protein quantification.
• Chemical Biology Tool: Employed in the design and synthesis of activity-based probes and other chemical tools for studying enzyme function and mechanism.

Basic Information

Product Name	Glycine-2,2-D2-n-T-Boc
CAS No.	42492-65-9
Molecular Formula	C7H11D2NO4
Molecular Weight	177.20 g/mol
Synonyms	N-(tert-Butoxycarbonyl)glycine-2,2-d2; Boc-Glycine-2,2-d2; (2,2-Dideuterioglycyl)carbamic acid tert-butyl ester; N-Boc-glycine-d2; tert-Butyl (2,2-dideuterioglycinate)carbamate; Glycine-2,2-d2, N-Boc-protected; Boc-Gly-d2; 2,2-Dideutero-N-(tert-butoxycarbonyl)glycine
EINECS	Contact for details

Quality Control

Every batch of Glycine-2,2-D2-n-T-Boc is manufactured and tested under strict quality management protocols. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with research-grade standards and isotopic purity specifications. Certificates of Analysis (COA) detailing assay, isotopic enrichment, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (argon or nitrogen) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.