Description

Pyrrolidine-2,2,5,5-D4 is a deuterated analog of pyrrolidine, where four hydrogen atoms are replaced with deuterium, a stable isotope of hydrogen. This deuteration is critical for applications requiring reduced metabolic lability and enhanced analytical sensitivity, such as in NMR spectroscopy and mass spectrometry. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, isotopically labeled building blocks for drug discovery, metabolic studies, and the development of organic electronic materials.

Application

• As a deuterated internal standard for the precise quantification of pyrrolidine and related compounds in complex matrices using LC-MS or GC-MS.
• A key deuterium-labeled building block in pharmaceutical research for synthesizing drug candidates with modified pharmacokinetic profiles.
• Used as a NMR solvent shift reagent and for mechanistic studies in organic and organometallic chemistry.
• Employed in the synthesis of deuterated polymers and advanced organic materials for optoelectronic applications.
• Facilitates metabolic pathway tracing in biological and environmental studies.
• Acts as a precursor for deuterated catalysts and ligands used in specialized chemical synthesis.

Basic Information

Product Name	Pyrrolidine-2,2,5,5-D4
CAS No.	42403-25-8
Molecular Formula	C4H5D4N
Molecular Weight	75.15 g/mol
Synonyms	Pyrrolidine-d4; Tetradeutero-pyrrolidine; Perdeuterated Pyrrolidine (partial); 2,2,5,5-Tetradeuteriopyrrolidine; 1-Azacyclopentane-2,2,5,5-d4; Tetra-deuterated Pyrrolidine; Deuterated Pyrrolidine (2,2,5,5-D4); Azolidine-d4
EINECS	Contact for details

Quality Control

Every batch of Pyrrolidine-2,2,5,5-D4 is produced and analyzed under strict quality management protocols to ensure exceptional isotopic and chemical purity. Our products undergo rigorous quality testing, including NMR, GC-MS, and HPLC analysis, to ensure compliance with customer specifications and industry standards. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and highly volatile nature, this material should be stored under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to reach ambient temperature before opening to minimize moisture ingress and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Isotopic Enrichment (D)	≥ 98 atom % D
Chemical Purity (GC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.