Description

Diazald(R)-n-Methyl-D3 CAS NO 42366-72-3 is a deuterated derivative of the classic methylating agent, N-Methyl-N-nitroso-p-toluenesulfonamide (Diazald). This compound is specifically designed for applications requiring the introduction of a deuterated methyl group, serving as a valuable reagent in the synthesis of isotopically labeled compounds. It is essential for researchers and manufacturers in pharmaceutical development, agrochemical research, and advanced material science who require precise isotopic labeling for metabolic studies, tracer analysis, or NMR spectroscopy. The product offers high isotopic purity and reliable performance for critical synthetic pathways.

Application

• Pharmaceutical Research & Development: Synthesis of deuterium-labeled drug candidates and metabolites for pharmacokinetic (ADME) studies, bioavailability assessments, and internal standards for mass spectrometry.
• Analytical Chemistry: Preparation of deuterated internal standards for use in quantitative LC-MS and GC-MS analysis to enhance accuracy and reliability in complex matrices.
• Agrochemical Science: Development of isotopically labeled pesticides, herbicides, and their degradation products for environmental fate and metabolism studies.
• Material Science: Incorporation of deuterium labels into polymers or organic semiconductors to study molecular dynamics, structure-property relationships, and degradation mechanisms.
• NMR Spectroscopy: Use as a precursor for preparing deuterated solvents or shift reagents, aiding in complex structural elucidation and reaction monitoring.
• Academic & Institutional Research: A key reagent in synthetic organic chemistry for mechanistic studies and the development of novel labeled synthetic methodologies.

Basic Information

Item	Detail
Product Name	Diazald(R)-n-Methyl-D3
CAS No.	42366-72-3
Molecular Formula	C8H8D3N2O3S
Molecular Weight	215.25 g/mol
Synonyms	N-Methyl-D3-N-nitroso-p-toluenesulfonamide; Deuterated Diazald; (4-Methylphenyl)sulfonyl(methyl-d3)nitrous amide; Methyl-d3-diazald; N-Nitroso-N-(methyl-d3)-4-toluenesulfonamide; p-Toluenesulfonyl(methyl-d3)nitrosamide; Diazald-d3; D3-Methyl Diazald
EINECS	Contact for details

Quality Control

Our Diazald(R)-n-Methyl-D3 is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chemical purity, isotopic enrichment (D-atom %), and impurity profile. We support compliance with cGMP and ICH guidelines for pharmaceutical applications. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (D-atom %)	≥ 98.0%
Melting Point	58 - 62 °C
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.