Description

3-(Trimethylsilyloxy)Propionitrile is a versatile organosilicon compound featuring a cyano group protected by a trimethylsilyl (TMS) ether, making it a valuable reagent in synthetic organic chemistry. Its primary value lies in its role as a protected cyanohydrin synthon, enabling the controlled introduction of nitrile and hydroxyl functionalities in complex molecule assembly. This intermediate is particularly essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used in the synthesis of active pharmaceutical ingredients (APIs), fine chemicals, and advanced materials.

Application

• Pharmaceutical Synthesis: A key protected intermediate for constructing β-hydroxy nitrile motifs found in various drug candidates and APIs.
• Agrochemical Manufacturing: Used in the synthesis of herbicides, fungicides, and insecticides that require cyanohydrin derivatives.
• Fine Chemical Production: Serves as a building block for specialty chemicals, flavors, and fragrances.
• Polymer & Material Science: Acts as a monomer or cross-linking agent in the development of specialty silicones and advanced polymers.
• Organic Synthesis Reagent: Utilized in nucleophilic addition reactions, Grignard reactions, and as a masked source of hydrogen cyanide.
• Protecting Group Strategy: The TMS group protects the labile cyanohydrin, allowing for selective reactions elsewhere in the molecule before deprotection.

Basic Information

Product Name	3-(Trimethylsilyloxy)Propionitrile
CAS No.	42202-44-8
Molecular Formula	C6H13NOSi
Molecular Weight	143.26 g/mol
Synonyms	3-(Trimethylsiloxy)propionitrile; Trimethylsilyloxypropionitrile; β-Trimethylsilyloxypropionitrile; 2-Cyanoethyl trimethylsilyl ether; NSC 334044; (Trimethylsilyloxy)acetonitrile, homologue; 3-[(Trimethylsilyl)oxy]propanenitrile
EINECS	Contact for details

Quality Control

Our 3-(Trimethylsilyloxy)Propionitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment to guarantee it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.