Description

2-Chloro-1-(3,4-Dihydro-1H-Isoquinolin-2-Yl)-Ethanone is a versatile and high-purity organic building block, specifically a chloroacetylated tetrahydroisoquinoline derivative. This compound is valued for its role as a key synthetic intermediate in the development of complex molecules, offering a reactive handle for further functionalization. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for use in medicinal chemistry, process development, and the synthesis of biologically active compounds.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potential drug candidates, particularly those targeting neurological and cardiovascular pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its reactive chloroacetyl group.
• Agrochemical Synthesis: Serves as a building block for developing novel pesticides and herbicides.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying enzyme function and biological mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and custom production projects.
• Academic Research: Employed in university and institutional labs for methodological development and novel heterocyclic chemistry.

Basic Information

Product Name	2-Chloro-1-(3,4-Dihydro-1H-Isoquinolin-2-Yl)-Ethanone
CAS No.	41910-57-0
Molecular Formula	C11H12ClNO
Molecular Weight	209.67 g/mol
Synonyms	2-Chloro-1-(1,2,3,4-tetrahydroisoquinolin-2-yl)ethanone; 2-Chloro-1-(3,4-dihydro-1H-isoquinolin-2-yl)ethan-1-one; N-Chloroacetyl-1,2,3,4-tetrahydroisoquinoline; 2-Chloro-N-(1,2,3,4-tetrahydroisoquinolin-2-yl)acetamide; Chloroacetyl tetrahydroisoquinoline; 41910-57-0; Ethanone, 2-chloro-1-(3,4-dihydro-1H-isoquinolin-2-yl)-
EINECS	Contact for details

Quality Control

Our 2-Chloro-1-(3,4-Dihydro-1H-Isoquinolin-2-Yl)-Ethanone is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Production adheres to cGMP guidelines where applicable. Every lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by HPLC, GC, NMR, and mass spectrometry. We support regulatory submissions with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.