Description

Bis(Trimethylsilyl)Trifluoro-Acetyl-Phosphonate is a specialized organosilicon reagent featuring a reactive phosphonate ester group flanked by trimethylsilyl and trifluoroacetyl functionalities. This compound is valued for its role as a key intermediate and protecting group reagent in advanced organic synthesis, particularly for introducing phosphorus-containing moieties under mild conditions. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Used in the synthesis of novel drug candidates, particularly those containing phosphonate or phosphate ester groups as bioisosteres.
• Peptide & Nucleotide Chemistry: Serves as a protecting and activating agent for the controlled phosphorylation and modification of biomolecules.
• Agrochemical Synthesis: A building block for creating advanced herbicides, insecticides, and plant growth regulators with enhanced properties.
• Ligand & Catalyst Development: Employed in the preparation of specialized phosphonate-based ligands for metal catalysis and coordination chemistry.
• Materials Science Precursor: Used in the development of flame-retardant additives, specialty polymers, and surface-modifying agents.
• Laboratory Reagent: A valuable tool for method development and exploratory research in academic and industrial R&D settings.

Basic Information

Product Name	Bis(Trimethylsilyl)Trifluoro-Acetyl-Phosphonate
CAS No.	41898-99-1
Molecular Formula	C10H22F3O4PSi2
Molecular Weight	350.41 g/mol
Synonyms	Bis(trimethylsilyl) (trifluoroacetyl)phosphonate; (Trifluoroacetyl)phosphonic Acid Bis(trimethylsilyl) Ester; Phosphonic acid, P-(trifluoroacetyl)-, bis(trimethylsilyl) ester; TMS-TFAP; BTSTFAP; Tris(trimethylsilyl) Trifluoroacetylphosphonite (common misnomer); Contact for additional trade names and abbreviations.
EINECS	Contact for details

Quality Control

Our Bis(Trimethylsilyl)Trifluoro-Acetyl-Phosphonate is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including NMR, HPLC, and Karl Fischer titration, to confirm identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to a quality management system and can support development projects requiring custom purity grades or specific impurity thresholds.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
NMR Purity (1H, 13C, 31P)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.