Description

N,o-Bis(tert-Butyldimethylsilyl)Hydroxylamine is a specialized organosilicon-protected hydroxylamine derivative, serving as a critical reagent in advanced synthetic organic chemistry. Its primary value lies in its role as a versatile nitrogen source and protecting group, enabling the controlled introduction of hydroxylamine functionality into complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for the synthesis of novel heterocycles, oximes, and other nitrogen-containing target molecules.

Application

• Pharmaceutical Intermediate Synthesis: Key building block for introducing protected hydroxylamine groups in the development of new active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides that require specific nitrogen-oxygen functionalities.
• Peptide & Protein Modification: Employed in the selective modification of amino acid side chains and the synthesis of chemically modified peptides.
• Polymer & Materials Science: Serves as a monomer or functionalization agent for creating polymers with tailored surface properties or reactivity.
• Cross-Coupling & Catalysis: Acts as a ligand precursor or reagent in metal-catalyzed reactions for C-N bond formation.
• Academic & Process R&D: A valuable tool for methodological development in organic synthesis and scaling up novel reaction pathways.

Basic Information

Product Name	N,o-Bis(tert-Butyldimethylsilyl)Hydroxylamine
CAS No.	41879-44-1
Molecular Formula	C12H31NOSi2
Molecular Weight	261.55 g/mol
Synonyms	N,O-Bis(tert-butyldimethylsilyl)hydroxylamine; N,O-Bis(TBDMS)hydroxylamine; Hydroxylamine, N,O-bis(1,1-dimethylethyl)dimethylsilyl-; Bis(tert-butyldimethylsilyl)hydroxylamine; TBDMS-protected hydroxylamine; N,O-Bis[(tert-butyldimethylsilyl)]hydroxylamine; N,O-Bis(t-butyldimethylsilyl)hydroxylamine; O,N-Bis(tert-butyldimethylsilyl)hydroxylamine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of research and process chemistry. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to standard analytical protocols including NMR, HPLC, and GC to verify specifications. Certificates are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.