Description

(-)-Ethotoin is a high-purity, single-enantiomer pharmaceutical intermediate and reference standard. This compound is critical for research and development in the pharmaceutical sector, particularly for neurological applications. It is primarily utilized by pharmaceutical manufacturers, R&D laboratories, and analytical service providers requiring a specific stereoisomer for process development, quality control, and advanced studies.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of specialized active pharmaceutical ingredients (APIs).
• Reference Standard: Used for analytical method development, validation, and quality control testing in pharmaceutical laboratories.
• Neurological Research: Employed in preclinical and clinical research studies investigating anticonvulsant mechanisms and structure-activity relationships.
• Process Chemistry: Serves as a critical starting material or intermediate in enantioselective synthesis routes.
• Impurity Standard: Used to identify and quantify the (-)-enantiomer as a potential impurity in batches of the racemic mixture or the opposite enantiomer.
• Regulatory Submissions: Provides essential characterization data for drug master files (DMFs) and regulatory dossiers.

Basic Information

Product Name	(-)-Ethotoin
CAS No.	41807-37-8
Molecular Formula	C11H14N2O2
Molecular Weight	206.24 g/mol
Synonyms	(-)-3-Ethyl-5-phenylhydantoin; (R)-3-Ethyl-5-phenylimidazolidine-2,4-dione; L-Ethotoin; (R)-Ethotoin; NSC 20268; 1-Ethyl-3-phenyl-2,4-imidazolidinedione (enantiomer)
EINECS	Contact for details

Quality Control

Our (-)-Ethotoin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay and identification of related substances, to ensure it meets stringent specifications for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, Chiral HPLC) are provided to guarantee identity, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.