Description

2-Bromo-4-(Trifluoromethyl)Thiazole is a high-value, halogenated heterocyclic building block essential for advanced organic synthesis. This compound matters for its unique trifluoromethyl and bromo substituents, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by manufacturers of specialty chemicals and materials science.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in antiviral, antibacterial, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the trifluoromethyl group enhances biological activity.
• Material Science Research: Serves as a precursor for functionalized polymers, liquid crystals, and other advanced materials requiring specific electronic properties.
• Chemical Biology & Proteomics: Employed as a reactive handle in bioconjugation chemistry and for the synthesis of molecular probes.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Negishi couplings to construct complex molecular architectures.
• Fluorine Chemistry Building Block: Integral for introducing the pharmacologically advantageous trifluoromethyl group into target molecules via further functionalization.

Basic Information

Product Name	2-Bromo-4-(Trifluoromethyl)Thiazole
CAS No.	41731-39-9
Molecular Formula	C4HBrF3NS
Molecular Weight	232.02 g/mol
Synonyms	2-Bromo-4-(trifluoromethyl)-1,3-thiazole; 4-(Trifluoromethyl)-2-bromothiazole; Thiazole, 2-bromo-4-(trifluoromethyl)-; 2-Bromo-4-trifluoromethylthiazole; 2-Bromo-α,α,α-trifluoro-4-thiazolemethanol (related); Bromo(trifluoromethyl)thiazole
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-4-(Trifluoromethyl)Thiazole is produced and tested under a strict quality management system. We ensure compliance with exacting standards for research and industrial use, with purity typically exceeding 97% (by GC/HPLC). A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee reliable and consistent performance in your synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.