Description

2-Bromo-4-Fluoro-1,3-Thiazole is a versatile halogenated heterocyclic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents on the thiazole ring, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides due to its bioactive heterocyclic core.
• Material Science Research: Serves as a building block for creating novel organic electronic materials, liquid crystals, and functional polymers.
• Chemical Biology & Proteomics: Employed as a reactive handle for bioconjugation and the synthesis of chemical probes to study biological systems.
• Cross-Coupling Reactions: The bromine atom is an excellent site for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to introduce complex substituents.
• Fluorine Chemistry: Provides a stable source of a fluorinated heterocycle for exploring structure-activity relationships (SAR) in drug discovery.

Basic Information

Product Name	2-Bromo-4-Fluoro-1,3-Thiazole
CAS No.	41731-36-6
Molecular Formula	C3HBrFNS
Molecular Weight	177.99 g/mol
Synonyms	4-Fluoro-2-bromothiazole; 2-Bromo-4-fluorothiazole; Thiazole, 2-bromo-4-fluoro-; 4-Fluoro-2-bromo-1,3-thiazole; 2-Bromo-4-fluoro-thiazole; Bromofluorothiazole
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our fine chemical intermediates. Every batch of 2-Bromo-4-Fluoro-1,3-Thiazole is analyzed using advanced techniques including GC, HPLC, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.