Description

n-[4-[(Trimethylsilyl)Oxy]Phenyl]Acetamide is a specialized organosilicon compound featuring a trimethylsilyl-protected phenolic group. This chemical is valued as a key synthetic intermediate and protecting group reagent in advanced organic synthesis, particularly for pharmaceuticals and fine chemicals. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a protected phenol precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing phenolic or catechol moieties.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and plant growth regulators where phenol protection is required.
• Fine Chemical Building Block: Acts as a versatile reagent for introducing the 4-(trimethylsilyloxy)phenylacetamide group into target molecules in custom synthesis and material science.
• Protecting Group Chemistry: The trimethylsilyl (TMS) group provides a stable, yet readily cleavable, protection for phenolic hydroxyl groups under mild conditions, facilitating multi-step synthetic sequences.
• Liquid Crystal & OLED Material Research: Potential intermediate in the development of organic semiconductors and advanced display materials due to its aromatic and silyl ether structure.

Basic Information

Product Name	n-[4-[(Trimethylsilyl)Oxy]Phenyl]Acetamide
CAS No.	41571-82-8
Molecular Formula	C11H17NO2Si
Molecular Weight	223.35 g/mol
Synonyms	4-(Trimethylsilyloxy)acetanilide; N-Acetyl-4-(trimethylsilyloxy)aniline; 4-Acetamidophenyl trimethylsilyl ether; p-(Trimethylsilyloxy)acetanilide; Acetamide, N-[4-[(trimethylsilyl)oxy]phenyl]-; 4-Hydroxyacetanilide trimethylsilyl ether; TMS-protected paracetamol derivative
EINECS	Contact for details

Quality Control

Our n-[4-[(Trimethylsilyl)Oxy]Phenyl]Acetamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can compromise product integrity. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.