Description

Codeine Phosphate is a white or almost white crystalline powder, widely recognized as a key pharmaceutical active ingredient. It is a vital opioid analgesic and antitussive agent, essential for the formulation of controlled pain relief and cough suppression medications. This high-purity compound is primarily utilized by pharmaceutical manufacturers, research institutions, and fine chemical suppliers serving the global healthcare sector.

Application

• Pharmaceutical Manufacturing: Primary active ingredient in prescription analgesic tablets and syrups for moderate pain management.
• Antitussive Formulations: Key component in cough suppressant medications, often in combination with other active ingredients.
• Clinical Research: Used as a reference standard and in pharmacological studies related to opioid receptors and pain pathways.
• Controlled Drug Production: Sourced by licensed facilities for the manufacture of Schedule II/V narcotic preparations as per national regulations.
• Analytical Chemistry: Serves as a high-purity standard for quality control laboratories performing HPLC or spectroscopic assays.

Basic Information

Product Name	Codeine Phosphate
CAS No.	41444-62-6
Molecular Formula	C18H24NO7P
Molecular Weight	397.36 g/mol
Synonyms	Morphine-3-methyl ether phosphate; Codeine phosphate hemihydrate; 3-Methoxy-17-methyl-7,8-didehydro-4,5α-epoxymorphinan-6α-ol phosphate; Methylmorphine phosphate; Codicept; Paveral; Codipront; Codimal; Codiphane; Coducept
EINECS	Contact for details

Quality Control

Our Codeine Phosphate is manufactured under strict quality management systems. It is tested to meet stringent pharmacopeial standards, including USP and EP monographs, ensuring identity, purity, strength, and composition. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing results for assay, related substances, residual solvents, and microbiological attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept in a low-humidity environment to prevent degradation. Ensure storage areas comply with all applicable regulations for controlled pharmaceutical substances.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to standard
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Water (KF)	≤ 6.0%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any individual impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Microbial Limits	Complies with USP <61> and <62>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.