Description

Para-Hydroxymethadone is a key pharmaceutical intermediate and reference standard of significant importance in analytical and research chemistry. Its primary value lies in its role as a metabolite and a high-purity chemical entity for method development and quality control. This compound is essential for pharmaceutical R&D laboratories, forensic analysis teams, and manufacturers of certified reference materials who require precise and reliable analytical standards.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the identification and quantification of methadone and its metabolites in drug testing and pharmacokinetic studies.
• Metabolite Research: Serves as a critical metabolite in studies investigating the metabolic pathways, bioavailability, and clearance of methadone.
• Forensic Toxicology: Employed in the calibration of analytical instruments (GC-MS, LC-MS/MS) for accurate detection in forensic and clinical toxicology reports.
• Method Development & Validation: Acts as a key component in developing and validating new chromatographic and spectroscopic analytical methods.
• Impurity Profiling: Used as an impurity marker in the quality control of methadone Active Pharmaceutical Ingredient (API) manufacturing to ensure product purity.
• Academic & Clinical Research: Facilitates pharmacological and biochemical research into opioid receptor interactions and metabolic studies.

Basic Information

Product Name	Para-Hydroxymethadone
CAS No.	41238-35-1
Molecular Formula	C21H27NO2
Molecular Weight	325.45 g/mol
Synonyms	4-Hydroxymethadone; (R,S)-6-(Dimethylamino)-4,4-diphenyl-3-heptanol; 2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine-4-ol; EDDP-OH; p-Hydroxymethadone; 4-Hydroxy-6-(dimethylamino)-4,4-diphenyl-3-heptanone (tautomeric form); Major Methadone Metabolite
EINECS	Contact for details

Quality Control

Our Para-Hydroxymethadone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis, to ensure it meets the high standards required for research and reference materials. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.