Description

D-Ethyl 1,2,3,4-Tetrahydroisoquinoline-3-Carboxylate Hydrochloride is a high-purity, pharmaceutically relevant chiral building block and synthetic intermediate. This compound is critical for research and development in medicinal chemistry, particularly for the synthesis of complex bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions focused on developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potential drug candidates, particularly those targeting neurological and cardiovascular systems.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the construction of tetrahydroisoquinoline-based compound libraries for high-throughput screening.
• Asymmetric Synthesis: Serves as a valuable starting material or intermediate in catalytic asymmetric transformations due to its defined stereochemistry.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and advanced materials.
• Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	D-Ethyl 1,2,3,4-Tetrahydroisoquinoline-3-Carboxylate Hydrochloride
CAS No.	41220-49-9
Molecular Formula	C₁₃H₁₇NO₂·HCl
Molecular Weight	255.74 g/mol
Synonyms	(3R)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid ethyl ester hydrochloride; D-THIQ-OEt·HCl; Ethyl (3R)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate hydrochloride; (R)-Ethyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride; (R)-ETIQ hydrochloride; (R)-Ethyl 3,4-dihydro-1H-isoquinoline-3-carboxylate hydrochloride; (R)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid ethyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our D-Ethyl 1,2,3,4-Tetrahydroisoquinoline-3-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.