Description

4,4'-Dimethoxy-4''-Methyltrityl Alcohol is a specialized trityl-protecting group reagent widely used in synthetic organic chemistry, particularly in oligonucleotide and peptide synthesis. Its core value lies in providing a robust, acid-labile protecting group for primary hydroxyl functions, enabling selective deprotection in complex multi-step syntheses. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors developing advanced therapeutics and nucleic acid-based products.

Application

• Oligonucleotide Synthesis: As a key protecting group reagent for the 5'-hydroxyl function in phosphoramidite-based solid-phase DNA/RNA synthesis.
• Peptide Synthesis: For the protection of serine, threonine, or other hydroxyl-containing amino acid side chains during SPPS (Solid-Phase Peptide Synthesis).
• Carbohydrate Chemistry: Selective protection of primary hydroxyl groups in complex sugar and nucleoside synthesis.
• Pharmaceutical Intermediates: A critical building block in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs requiring orthogonal protection strategies.
• Research & Development: Used in academic and industrial R&D labs for exploring new synthetic methodologies and constructing complex molecular architectures.
• Fine Chemical Production: Manufacture of specialty chemicals, catalysts, and advanced materials where precise hydroxyl group masking is required.

Basic Information

Product Name	4,4'-Dimethoxy-4''-Methyltrityl Alcohol
CAS No.	41032-95-5
Molecular Formula	C22H22O3
Molecular Weight	334.41 g/mol
Synonyms	MMT-OH; 4-Monomethoxytrityl Alcohol; 4'-Methyl-4,4''-dimethoxytrityl Alcohol; (4-Methoxyphenyl)bis(4-methylphenyl)methanol; 4,4'-Dimethoxy-4''-methyltriphenylmethanol; 4-Monomethoxytrityl Alcohol (MMT-OH); α-(4-Methoxyphenyl)-α-(4-methylphenyl)-4-methoxybenzenemethanol
EINECS	Contact for details

Quality Control

Our 4,4'-Dimethoxy-4''-Methyltrityl Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality parameters. Our production adheres to cGMP principles where applicable, ensuring consistent quality and reliable supply for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.