Description

1-Aminoadamantane-N,n-D2 is a deuterated derivative of amantadine, featuring two deuterium atoms on the amine group. This deuteration is critical for enhancing metabolic stability and reducing the rate of hydrogen-deuterium exchange in research applications, making it a valuable tool in mechanistic and pharmacokinetic studies. It is primarily utilized by pharmaceutical R&D laboratories and chemical manufacturers focused on developing and scaling up novel active pharmaceutical ingredients (APIs), diagnostic agents, and stable isotope-labeled reference standards.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel antiviral and neurological drug candidates.
• Metabolic Tracer: Used in mass spectrometry and NMR-based studies to track drug metabolism and distribution pathways.
• Stable Isotope-Labeled Standard: Essential for the development of quantitative analytical methods (e.g., LC-MS/MS) for bioanalysis and pharmacokinetic profiling.
• Mechanistic Probe: Employed in chemical and biochemical research to investigate reaction mechanisms and enzyme kinetics through kinetic isotope effect (KIE) studies.
• Material Science Research: Investigated as a precursor for advanced organic frameworks or functionalized polymers with specific deuterium labeling.

Basic Information

Product Name	1-Aminoadamantane-N,n-D2
CAS No.	40933-03-7
Molecular Formula	C10H15D2N
Molecular Weight	155.26 g/mol
Synonyms	Adamantan-1-amine-N,N-d2; 1-Adamantylamine-N,N-d2; 1-Aminotricyclo[3.3.1.13,7]decane-N,N-d2; Deuterated Amantadine (N,N-d2); 1-Adamantanamine-N,N-d2; NSC 83656-d2; 1-Aminoadamantane-d2 (amine labeled)
EINECS	Contact for details

Quality Control

Every batch of 1-Aminoadamantane-N,n-D2 is produced and tested under strict quality management protocols to ensure high chemical purity and isotopic enrichment. Our standard quality assurance includes comprehensive analysis via NMR, HPLC, and MS to confirm identity, chemical purity, and deuterium incorporation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications. We support compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Incorporation (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.