Description

2-Hydroxy-2-Methyl-D3-Propionic-3,3,3-D3 Acid is a high-purity, deuterium-labeled isotopologue of 2-hydroxy-2-methylpropionic acid (hydroxypivalic acid). This compound is essential for advanced analytical and research applications where precise molecular tracking and quantification are required. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries for use as an internal standard in mass spectrometry, metabolic pathway studies, and the synthesis of labeled compounds. The product is supplied under strict quality control to ensure isotopic purity and chemical integrity.

Application

• Internal Standard for Quantitative Analysis: Used in LC-MS and GC-MS for the accurate quantification of 2-hydroxy-2-methylpropionic acid and related metabolites in complex biological matrices.
• Metabolic Pathway Tracing: A critical tool in pharmaceutical and biochemical research for studying drug metabolism, degradation pathways, and biosynthetic routes using deuterium as a stable isotopic tracer.
• Synthesis of Deuterated Compounds: Serves as a key labeled building block for the preparation of more complex deuterated molecules for research and development.
• NMR Spectroscopy: Employed as a standard or reference compound in nuclear magnetic resonance studies due to its distinct spectral signature.
• Pharmaceutical Impurity Profiling: Assists in the identification and quantification of process-related impurities and degradation products during drug development and quality control.
• Environmental and Food Analysis: Applied in trace analysis methods to monitor residues or natural compounds in environmental and food samples.

Basic Information

Product Name	2-Hydroxy-2-Methyl-D3-Propionic-3,3,3-D3 Acid
CAS No.	40662-45-1
Molecular Formula	C4D6O3
Molecular Weight	108.12 g/mol
Synonyms	Hydroxypivalic Acid-d6; 2-Hydroxy-2-methylpropionic Acid-d6; 2-Hydroxyisobutyric Acid-d6; (D3C)3CCOOD; 2-Methyl-2-hydroxypropionic Acid-d6; α-Hydroxyisobutyric Acid-d6; 2-Hydroxy-2-(trideuteriomethyl)propionic-3,3,3-d3 Acid; HMB-d6
EINECS	Contact for details

Quality Control

Every batch of 2-Hydroxy-2-Methyl-D3-Propionic-3,3,3-D3 Acid is manufactured and tested to meet exacting standards for isotopic and chemical purity. Our quality assurance protocol includes comprehensive analysis via NMR, MS, and HPLC to verify identity, isotopic enrichment (typically >98 atom % D), and chemical purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications. We adhere to cGMP principles for the production of high-value research chemicals to ensure batch-to-batch consistency and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.